One of the best Point&Click adventure games ever created is called Broken Sword. ("Baphomets Fluch" as in the german version)
While progressing in this game, George travals all around the world to find the murderer. Later in the game there are many possibilities to die, which are hardly avoidable when playing for the first time.
Although i like nearly all Point&Click adventures, this one is a special. You are not in a fantasy world and don't want to become a pirate (:>). You are just a normal person and want to find a murderer. It feels like you're right in a crime thriller. Additionally the researches in history facts reminds one of movies like "The Da Vinci Code" or "National Treasure".
Meanwhile there exist 4 official games. The first 2 are controlled by traditional Point&Click mechanism. Part 3 was the first with 3D graphics and is controlled either with a gamepad or keyboard. Part 4 has also 3D graphics but Point&Click control were used again.
Other than these 4 there was a fanproject called "Broken Sword 2.5" created by MindFactory.
I recommend to play at least part 1 and part 2, those were definitely the best of the series.
Thanks for reading :)